Mayesville is a town in Lee County, South Carolina, home to about 832 people across 1.0 square miles. Its ZIP code is 29104.
Homes sold for a median of $133 per square foot in the three months ending August 2026, a seller’s market.
Mostly Mayesville; also St. Charles
Each card is that ZIP code’s whole market, including any part outside Mayesville. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Mayesville’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | Charleston International Airport (CHS)74 miles away |
|---|---|
| Closer regional airport | Florence Regional Airport (FLO)33 miles away |
| Nearest city of 250,000+ | Charlotte, NC94 miles away |
| Nearest city of 1 million+ | Philadelphia, PA504 miles away |
Straight-line distances from the center of Mayesville; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Mayesville had 548 residents in the 2020 census, down 45% since 2000.
It’s the 288th largest of 474 towns in South Carolina by population.
Lee County grew from 25,318 residents in 1910 to 16,531 in 2020.
Lee County, 1910–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 90°F in summer, and winter lows average 33°F. About 49 inches of rain and melted snow fall in a typical year, with about 0 inches of snow.
Source: NOAA 1991–2020 climate normals, Sumter, SC weather station (8 miles away).
2,246 jobs at 212 businesses in Lee County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
Nearest hospitals
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances.
Public schools here are run by Lee 01. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Lower Lee ElementaryMayesville | Pre-K–5 | 128 | Public | 9.2 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools. Listed by address; we don’t rate schools.
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Shares ZIP codes with St. Charles.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.