Santee is a town in Orangeburg County, South Carolina, home to about 1,076 people across 2.1 square miles. It has no ZIP code of its own: it’s part of 29142.
Homes sold for a median of $170 per square foot in the three months ending August 2026, a balanced market.
Each card is that ZIP code’s whole market, including any part outside Santee. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
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| Nearest major airport | Charleston International Airport (CHS)48 miles away |
|---|---|
| Nearest city of 250,000+ | Charlotte, NC121 miles away |
| Nearest city of 1 million+ | Philadelphia, PA539 miles away |
Straight-line distances from the center of Santee; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Santee had 797 residents in the 2020 census, up 8% since 2000.
It’s the 261st largest of 474 towns in South Carolina by population.
Orangeburg County grew from 59,663 residents in 1900 to 84,223 in 2020.
Orangeburg County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 91°F in summer, and winter lows average 35°F. About 50.5 inches of rain and melted snow fall in a typical year.
Source: NOAA 1991–2020 climate normals, Holly Hill 1 Sw, SC weather station (12 miles away).
25,672 jobs at 1,630 businesses in Orangeburg County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
7 doctors and other health care providers list an office in Santee.
Nearest hospitals
Providers with an office here
| Specialist doctors | 1 |
|---|---|
| Nurse practitioners and physician assistants | 2 |
| Mental health providers | 3 |
| Chiropractors | 1 |
| Pharmacies | 2 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Grocery stores (2 nearby)
Pharmacies (1 nearby)
Libraries (1 nearby)
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Public schools here are run by Orangeburg. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Lake Marion High SchoolSantee | 9–12 | 692 | Public | 3.3 mi |
| Lake Marion Technology CenterSantee | 9–12 | — | Career and Technical | 3.3 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools. Listed by address; we don’t rate schools.
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Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.