Fredericktown is a city in Madison County, Missouri, home to about 4,507 people across 4.3 square miles. Its ZIP code is 63645.
Homes sold for a median of $132 per square foot in the three months ending August 2026, a balanced market.
Mostly Fredericktown; also Junction City and Mine La Motte
Each card is that ZIP code’s whole market, including any part outside Fredericktown. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
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| Nearest major airport | St. Louis Lambert International Airport (STL)87 miles away |
|---|---|
| Closer regional airport | Cape Girardeau Regional Airport (CGI)46 miles away |
| Nearest city of 250,000+ | St. Louis, MO79 miles away |
| Nearest city of 1 million+ | Chicago, IL332 miles away |
Straight-line distances from the center of Fredericktown; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Fredericktown had 4,429 residents in the 2020 census, up 13% since 2000.
It’s the 165th largest of 1,060 towns in Missouri by population.
Madison County grew from 9,975 residents in 1900 to 12,626 in 2020.
Madison County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 88°F in summer, and winter lows average 21°F. About 46.4 inches of rain and melted snow fall in a typical year, with about 9 inches of snow.
Source: NOAA 1991–2020 climate normals, Fredericktown, MO weather station (6 miles away).
3,148 jobs at 231 businesses in Madison County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
64 doctors and other health care providers list an office in Fredericktown.
Nearest hospitals
Providers with an office here
| Primary care doctors | 10 |
|---|---|
| Specialist doctors | 1 |
| Dentists | 3 |
| Nurse practitioners and physician assistants | 14 |
| Mental health providers | 28 |
| Physical and occupational therapists | 5 |
| Optometrists | 1 |
| Chiropractors | 2 |
| Pharmacies | 8 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Grocery stores
Libraries
Counts are within about 1.5 miles of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Public schools here are run by Fredericktown R-I. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Fredericktown Elem.Fredericktown | Pre-K–2 | 446 | Public | 5.1 mi |
| Fredericktown IntermediateFredericktown | 3–5 | 393 | Public | 6.2 mi |
| Kelly A Burlison Middle SchoolFredericktown | 6–8 | 433 | Public | 6.1 mi |
| Fredericktown HighFredericktown | 9–12 | 611 | Public | 6.1 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools. Listed by address; we don’t rate schools.
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Shares ZIP codes with Junction City, Mine La Motte, Cobalt and Cherokee Pass.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.