Pilot Knob is a city in Iron County, Missouri, home to about 653 people across 0.9 square miles. Its ZIP code is 63663, and parts of 63650 are in Pilot Knob too.
Homes sold for a median of $130 per square foot in the three months ending August 2026, a seller’s market.
Mostly Pilot Knob
Mostly Ironton; part is in Pilot Knob
Each card is that ZIP code’s whole market, including any part outside Pilot Knob. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Pilot Knob’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | St. Louis Lambert International Airport (STL)79 miles away |
|---|---|
| Closer regional airport | Cape Girardeau Regional Airport (CGI)65 miles away |
| Nearest city of 250,000+ | St. Louis, MO73 miles away |
| Nearest city of 1 million+ | Chicago, IL330 miles away |
Straight-line distances from the center of Pilot Knob; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Pilot Knob had 671 residents in the 2020 census, down 4% since 2000.
It’s the 466th largest of 1,060 towns in Missouri by population.
Iron County grew from 8,716 residents in 1900 to 9,537 in 2020.
Iron County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 89°F in summer, and winter lows average 23°F. About 45.4 inches of rain and melted snow fall in a typical year, with about 9 inches of snow.
Source: NOAA 1991–2020 climate normals, Farmington, MO weather station (17 miles away).
1,822 jobs at 193 businesses in Iron County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
14 doctors and other health care providers list an office in Pilot Knob.
Nearest hospitals
Providers with an office here
| Primary care doctors | 3 |
|---|---|
| Dentists | 1 |
| Nurse practitioners and physician assistants | 7 |
| Mental health providers | 2 |
| Chiropractors | 1 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (1 nearby)
Grocery stores (1 nearby)
Libraries
Museums (1 nearby)
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
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Shares ZIP codes with Ironton, Iron Mountain Lake and Arcadia.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.