East Prairie is a city in Mississippi County, Missouri, home to about 2,902 people across 1.3 square miles. Its ZIP code is 63845.
Homes sold for a median of $91 per square foot in the three months ending August 2026, a balanced market.
Mostly East Prairie; also Whiting
Each card is that ZIP code’s whole market, including any part outside East Prairie. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up East Prairie’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | Frederick W. Smith International Airport (MEM)124 miles away |
|---|---|
| Closer regional airport | Cape Girardeau Regional Airport (CGI)33 miles away |
| Nearest city of 250,000+ | Memphis, TN120 miles away |
| Nearest city of 1 million+ | Chicago, IL361 miles away |
Straight-line distances from the center of East Prairie; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
East Prairie had 2,943 residents in the 2020 census, down 9% since 2000.
It’s the 209th largest of 1,060 towns in Missouri by population.
Mississippi County grew from 11,837 residents in 1900 to 12,577 in 2020.
Mississippi County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 91°F in summer, and winter lows average 28°F. About 49.8 inches of rain and melted snow fall in a typical year, with about 3 inches of snow.
Source: NOAA 1991–2020 climate normals, Sikeston Pwr Stn, MO weather station (15 miles away).
1,966 jobs at 214 businesses in Mississippi County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
8 doctors and other health care providers list an office in East Prairie.
Nearest hospitals
Providers with an office here
| Primary care doctors | 2 |
|---|---|
| Nurse practitioners and physician assistants | 4 |
| Mental health providers | 2 |
| Pharmacies | 4 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (1 nearby)
Grocery stores
Pharmacies (1 nearby)
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Established in 1881.
Source: Wikidata (wikidata.org), the free knowledge base; people are listed by place of birth.
Public schools here are run by East Prairie R-II. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| East Prairie ElemEast Prairie | Pre-K–4 | 412 | Public | 0.2 mi |
| East Prairie MiddleEast Prairie | 5–8 | 290 | Public | 0.4 mi |
| East Prairie HighEast Prairie | 9–12 | 301 | Public | 0.4 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools. Listed by address; we don’t rate schools.
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Shares ZIP codes with Whiting.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.