Sikeston is a city in Scott County, Missouri, home to about 16,320 people across 17 square miles. Its ZIP code is 63801.
Homes sold for a median of $121 per square foot in the three months ending August 2026, a seller’s market.
Each card is that ZIP code’s whole market, including any part outside Sikeston. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Sikeston’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | Frederick W. Smith International Airport (MEM)129 miles away |
|---|---|
| Closer regional airport | Cape Girardeau Regional Airport (CGI)23 miles away |
| Nearest city of 250,000+ | Memphis, TN125 miles away |
| Nearest city of 1 million+ | Chicago, IL356 miles away |
Straight-line distances from the center of Sikeston; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Sikeston had 16,291 residents in the 2020 census, down 4% since 2000.
It’s the 52nd largest of 1,060 towns in Missouri by population.
Scott County grew from 13,092 residents in 1900 to 38,059 in 2020.
Scott County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 91°F in summer, and winter lows average 28°F. About 49.8 inches of rain and melted snow fall in a typical year, with about 3 inches of snow.
Source: NOAA 1991–2020 climate normals, Sikeston Pwr Stn, MO weather station (2 miles away).
14,139 jobs at 970 businesses in Scott County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
319 doctors and other health care providers list an office in Sikeston.
Nearest hospitals
Providers with an office here
| Primary care doctors | 27 |
|---|---|
| Specialist doctors | 38 |
| Dentists | 22 |
| Nurse practitioners and physician assistants | 76 |
| Mental health providers | 74 |
| Physical and occupational therapists | 71 |
| Optometrists | 6 |
| Chiropractors | 5 |
| Pharmacies | 17 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (4 nearby)
Grocery stores (5 nearby)
Pharmacies (3 nearby)
Libraries (1 nearby)
Museums (1 nearby)
Counts are within about 3 miles of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Established in 1860.
Notable people born here
Source: Wikidata (wikidata.org), the free knowledge base; people are listed by place of birth.
Public schools here are run by Scott Co. Central, Sikeston R-6, Mo Schls for the Sev Disabled and others. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Scott Co. Central Elem.Sikeston | Pre-K–6 | 194 | Public | 6.6 mi |
| Sikeston Kindergarten Ctr.Sikeston | Pre-K–K | 403 | Public | 0.5 mi |
| New Dawn SchoolSikeston | K–12 | 28 | Special Education | 2.2 mi |
| Lee Hunter Elem.Sikeston | 1–4 | 369 | Public | 1.0 mi |
| Southeast Elem.Sikeston | 1–4 | 250 | Public | 2.2 mi |
| Wing Elem.Sikeston | 1–4 | 359 | Public | 2.1 mi |
| Sikeston Middle SchoolSikeston | 5–6 | 493 | Public | 1.3 mi |
| Sikeston Hope Ctr.Sikeston | 6–12 | 11 | Public | 1.1 mi |
| Scott Co. Central HighSikeston | 7–12 | 108 | Public | 6.6 mi |
| Sikeston Junior High SchoolSikeston | 7–8 | 448 | Public | 1.3 mi |
| Sikeston Career Tech. Ctr.Sikeston | 9–12 | — | Career and Technical | 1.0 mi |
| Sikeston Senior High SchoolSikeston | 9–12 | 955 | Public | 1.0 mi |
| School | Grades | Students | Affiliation | Distance |
|---|---|---|---|---|
| St Francis Xavier SchoolSikeston | Pre-K–8 | 63 | Roman Catholic | 1.2 mi |
| The Christian AcademySikeston | Pre-K–11 | 72 | Baptist | 1.2 mi |
| The Christian AcademySikeston | Pre-K–11 | 72 | Christian (no specific denomination) | 1.2 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools; Private School Universe Survey (2023-2024) for private schools. Listed by address; we don’t rate schools.
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