Defiance is a community in St. Charles County, Missouri, home to about 63 people across 1.0 square miles. It has no ZIP code of its own: it’s part of 63341.
Homes sold for a median of $224 per square foot in the three months ending August 2026, a seller’s market.
Part is in Defiance, part in New Melle
Each card is that ZIP code’s whole market, including any part outside Defiance. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Defiance’s story and what everyday life there is like, for people thinking about moving in.
Are you a local agent who knows Defiance well? Agents who advertise here will be able to write the guide. Advertise on OfferBacked
| Nearest major airport | St. Louis Lambert International Airport (STL)26 miles away |
|---|---|
| Nearest city of 250,000+ | St. Louis, MO32 miles away |
| Nearest city of 1 million+ | Chicago, IL275 miles away |
Straight-line distances from the center of Defiance; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Defiance had 159 residents in the 2020 census, up 3% since 2010.
It’s the 953rd largest of 1,060 towns in Missouri by population.
St. Charles County grew from 24,474 residents in 1900 to 405,262 in 2020.
St. Charles County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 88°F in summer, and winter lows average 21°F. About 44.4 inches of rain and melted snow fall in a typical year, with about 14 inches of snow.
Source: NOAA 1991–2020 climate normals, Weldon Spring Nws, MO weather station (8 miles away).
143,624 jobs at 8,946 businesses in St. Charles County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
3 doctors and other health care providers list an office in Defiance.
Nearest hospitals
Providers with an office here
| Specialist doctors | 1 |
|---|---|
| Mental health providers | 2 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Buying or selling around Defiance? Tell us what you need and when. No agents advertise here yet, so we’ll keep your request for up to 30 days and send it to local agents who join. No obligation, and you choose who to work with.
Loading map…
Shares ZIP codes with New Melle.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.