New Melle is a city in St. Charles County, Missouri, home to about 452 people across 1.7 square miles. Its ZIP code is 63365, and parts of 63341 and 63385 are in New Melle too.
Homes sold for a median of $207 per square foot across 2 ZIP codes in the three months ending August 2026, and all of them were seller’s markets.
All in New Melle
Part is in New Melle, part in Defiance
Mostly Wentzville; part is in New Melle
Each card is that ZIP code’s whole market, including any part outside New Melle. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up New Melle’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | St. Louis Lambert International Airport (STL)26 miles away |
|---|---|
| Nearest city of 250,000+ | St. Louis, MO34 miles away |
| Nearest city of 1 million+ | Chicago, IL269 miles away |
Straight-line distances from the center of New Melle; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
New Melle had 541 residents in the 2020 census, up 336% since 2000.
It’s the 538th largest of 1,060 towns in Missouri by population.
St. Charles County grew from 24,474 residents in 1900 to 405,262 in 2020.
St. Charles County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 88°F in summer, and winter lows average 21°F. About 44.4 inches of rain and melted snow fall in a typical year, with about 14 inches of snow.
Source: NOAA 1991–2020 climate normals, Weldon Spring Nws, MO weather station (11 miles away).
143,624 jobs at 8,946 businesses in St. Charles County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
5 doctors and other health care providers list an office in New Melle.
Nearest hospitals
Providers with an office here
| Specialist doctors | 1 |
|---|---|
| Dentists | 1 |
| Nurse practitioners and physician assistants | 1 |
| Optometrists | 1 |
| Chiropractors | 1 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Grocery stores
Pharmacies
Libraries
Theaters and performance venues
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
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Shares ZIP codes with Wentzville, O'Fallon, Josephville, Flint Hill and Defiance.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.