Chillicothe is a city in Ross County, Ohio, home to about 21,902 people across 11 square miles. Its ZIP code is 45601.
Homes sold for a median of $161 per square foot in the three months ending August 2026, a seller’s market.
Mostly Chillicothe; also Massieville and Andersonville
Each card is that ZIP code’s whole market, including any part outside Chillicothe. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Chillicothe’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | John Glenn Columbus International Airport (CMH)46 miles away |
|---|---|
| Closer regional airport | Rickenbacker International Airport (LCK)33 miles away |
| Nearest city of 250,000+ | Columbus, OH45 miles away |
| Nearest city of 1 million+ | Chicago, IL301 miles away |
Straight-line distances from the center of Chillicothe; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Chillicothe had 22,059 residents in the 2020 census, up 1% since 2000.
It’s the 76th largest of 1,264 towns in Ohio by population.
Ross County grew from 40,940 residents in 1900 to 77,093 in 2020.
Ross County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 86°F in summer, and winter lows average 22°F. About 43.7 inches of rain and melted snow fall in a typical year, with about 12 inches of snow.
Source: NOAA 1991–2020 climate normals, Waverly, OH weather station (16 miles away).
24,319 jobs at 1,245 businesses in Ross County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
1,202 doctors and other health care providers list an office in Chillicothe.
Nearest hospitals
Providers with an office here
| Primary care doctors | 148 |
|---|---|
| Specialist doctors | 169 |
| Dentists | 50 |
| Nurse practitioners and physician assistants | 234 |
| Mental health providers | 492 |
| Physical and occupational therapists | 44 |
| Optometrists | 40 |
| Chiropractors | 25 |
| Pharmacies | 21 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (6 nearby)
Grocery stores (5 nearby)
Pharmacies (3 nearby)
Libraries (3 nearby)
Museums (3 nearby)
Theaters and performance venues
Counts are within about 2.5 miles of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Established in 1803.
Notable people born here
Source: Wikidata (wikidata.org), the free knowledge base; people are listed by place of birth.
Public schools here are run by Chillicothe City, Southeastern Local, Union-Scioto Local and others. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Mt. Logan Early Childhood CenterChillicothe | Pre-K | 99 | Public | 1.7 mi |
| Southeastern Elementary SchoolChillicothe | Pre-K–4 | 381 | Public | 7.4 mi |
| Unioto ElementaryChillicothe | Pre-K–5 | 1,032 | Public | 2.6 mi |
| Zane Trace Elementary SchoolChillicothe | Pre-K–4 | 473 | Public | 6.8 mi |
| Chillicothe Primary SchoolChillicothe | K–2 | 572 | Public | 0.2 mi |
| Huntington Elementary SchoolChillicothe | K–4 | 404 | Public | 7.4 mi |
| Pickaway-Ross Career & Technology CenterChillicothe | 1–12 | 760 | Career and Technical | 7.2 mi |
| Chillicothe Intermediate SchoolChillicothe | 3–6 | 719 | Public | 1.0 mi |
| Huntington Middle SchoolChillicothe | 5–8 | 313 | Public | 7.4 mi |
| Southeastern Middle SchoolChillicothe | 5–8 | 281 | Public | 7.4 mi |
| Zane Trace Middle SchoolChillicothe | 5–8 | 392 | Public | 6.8 mi |
| Unioto Middle SchoolChillicothe | 6–8 | 486 | Public | 2.3 mi |
| Chillicothe Middle SchoolChillicothe | 7–8 | 404 | Public | 0.2 mi |
| Chillicothe High SchoolChillicothe | 9–12 | 795 | Public | 0.2 mi |
| Huntington High SchoolChillicothe | 9–12 | 300 | Public | 7.4 mi |
| Southeastern High SchoolChillicothe | 9–12 | 251 | Public | 7.4 mi |
| Southern Ohio Career AcademyChillicothe | 9–12 | 48 | Charter | 0.6 mi |
| Unioto High SchoolChillicothe | 9–12 | 578 | Public | 2.3 mi |
| Zane Trace High SchoolChillicothe | 9–12 | 330 | Public | 6.8 mi |
| School | Grades | Students | Affiliation | Distance |
|---|---|---|---|---|
| Bishop Flaget SchoolChillicothe | Pre-K–8 | 172 | Roman Catholic | 1.2 mi |
| Ross County Christian AcademyChillicothe | Pre-K–12 | 364 | Christian (no specific denomination) | 3.2 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools; Private School Universe Survey (2023-2024) for private schools. Listed by address; we don’t rate schools.
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Shares ZIP codes with Massieville and Andersonville.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.