Santee is a village in Knox County, Nebraska, home to about 235 people across 0.6 square miles. It has no ZIP code of its own: it’s part of 68760.
Mostly Niobrara; part is in Santee
We’re writing up Santee’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | Eppley Airfield (OMA)144 miles away |
|---|---|
| Closer regional airport | Sioux Gateway Airport / Brigadier General Bud Day Field (SUX)82 miles away |
| Nearest city of 250,000+ | Omaha, NE140 miles away |
| Nearest city of 1 million+ | Chicago, IL527 miles away |
Straight-line distances from the center of Santee; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Santee had 424 residents in the 2020 census, up 40% since 2000.
It’s the 326th largest of 580 towns in Nebraska by population.
Knox County grew from 14,343 residents in 1900 to 8,391 in 2020.
Knox County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 88°F in summer, and winter lows average 13°F. About 24.2 inches of rain and melted snow fall in a typical year.
Source: NOAA 1991–2020 climate normals, Niobrara, NE weather station (6 miles away).
1,459 jobs at 249 businesses in Knox County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
9 doctors and other health care providers list an office in Santee.
Nearest hospitals
Providers with an office here
| Primary care doctors | 1 |
|---|---|
| Dentists | 1 |
| Nurse practitioners and physician assistants | 3 |
| Mental health providers | 4 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Public schools here are run by Isanti Community School, Niobrara Public Schools. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Isanti Elementary SchoolNiobrara | Pre-K–5 | 120 | Public | 7.9 mi |
| Niobrara Elementary SchoolNiobrara | Pre-K–6 | 134 | Public | 5.3 mi |
| Isanti Middle SchoolNiobrara | 6–8 | 49 | Public | 7.9 mi |
| Niobrara Secondary SchoolNiobrara | 7–12 | 77 | Public | 5.3 mi |
| Isanti High SchoolNiobrara | 9–12 | 39 | Public | 7.9 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools. Listed by address; we don’t rate schools.
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Shares ZIP codes with Niobrara and Verdel.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.