Knob Lick is a community in St. Francois County, Missouri, home to about 41 people across 1.0 square miles. It has no ZIP code of its own: it’s part of 63640.
Homes sold for a median of $154 per square foot in the three months ending August 2026, a seller’s market.
Mostly Farmington; part is in Knob Lick
Each card is that ZIP code’s whole market, including any part outside Knob Lick. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Knob Lick’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | St. Louis Lambert International Airport (STL)67 miles away |
|---|---|
| Closer regional airport | Cape Girardeau Regional Airport (CGI)60 miles away |
| Nearest city of 250,000+ | St. Louis, MO60 miles away |
| Nearest city of 1 million+ | Chicago, IL315 miles away |
Straight-line distances from the center of Knob Lick; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
It’s the 995th largest of 1,060 towns in Missouri by population.
St. Francois County grew from 24,051 residents in 1900 to 66,922 in 2020.
St. Francois County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 89°F in summer, and winter lows average 23°F. About 45.4 inches of rain and melted snow fall in a typical year, with about 9 inches of snow.
Source: NOAA 1991–2020 climate normals, Farmington, MO weather station (about a mile away).
17,990 jobs at 1,438 businesses in St. Francois County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
492 doctors and other health care providers list an office in Knob Lick.
Nearest hospitals
Providers with an office here
| Primary care doctors | 47 |
|---|---|
| Specialist doctors | 56 |
| Dentists | 25 |
| Nurse practitioners and physician assistants | 101 |
| Mental health providers | 192 |
| Physical and occupational therapists | 51 |
| Optometrists | 6 |
| Chiropractors | 14 |
| Pharmacies | 20 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (6 nearby)
Grocery stores
Libraries (1 nearby)
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Public schools here are run by Farmington R-Vii, Department of Corrections. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Truman Learning CenterFarmington | Pre-K–K | 403 | Public | 0.9 mi |
| Juvenile Detention Ctr.Farmington | K–12 | 9 | Alternative Education | 0.5 mi |
| Jefferson Elem.Farmington | 1–4 | 343 | Public | 1.4 mi |
| Roosevelt Elem.Farmington | 1–4 | 387 | Public | 0.2 mi |
| Washington-Franklin Elem.Farmington | 1–4 | 363 | Public | 0.8 mi |
| Lincoln IntermediateFarmington | 5–6 | 521 | Public | 0.3 mi |
| Farmington Correctional CenterFarmington | 7–12 | — | Alternative Education | 1.6 mi |
| Farmington MiddleFarmington | 7–8 | 557 | Public | 0.2 mi |
| Farmington Treatment CenterFarmington | 7–12 | — | Alternative Education | 1.6 mi |
| Farmington Sr.. HighFarmington | 9–12 | 1,354 | Public | 1.5 mi |
| School | Grades | Students | Affiliation | Distance |
|---|---|---|---|---|
| St Joseph SchoolFarmington | Pre-K–8 | 131 | Roman Catholic | 0.4 mi |
| St Paul Lutheran SchoolFarmington | Pre-K–8 | 187 | Lutheran Church–Missouri Synod | 0.3 mi |
| St Paul Lutheran High SchoolFarmington | 9–12 | 70 | Lutheran Church–Missouri Synod | 2.9 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools; Private School Universe Survey (2023-2024) for private schools. Listed by address; we don’t rate schools.
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Shares ZIP codes with Farmington, Park Hills and Leadington.
Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.