Greenville is a city in Wayne County, Missouri, home to about 418 people across 0.7 square miles. Its ZIP code is 63944.
Homes sold for a median of $79 per square foot in the three months ending August 2026, a buyer’s market.
Each card is that ZIP code’s whole market, including any part outside Greenville. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Greenville’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | St. Louis Lambert International Airport (STL)113 miles away |
|---|---|
| Closer regional airport | Cape Girardeau Regional Airport (CGI)49 miles away |
| Nearest city of 250,000+ | St. Louis, MO106 miles away |
| Nearest city of 1 million+ | Chicago, IL358 miles away |
Straight-line distances from the center of Greenville; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Greenville had 443 residents in the 2020 census, down 2% since 2000.
It’s the 561st largest of 1,060 towns in Missouri by population.
Wayne County grew from 15,309 residents in 1900 to 10,974 in 2020.
Wayne County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 88°F in summer, and winter lows average 24°F. About 51.6 inches of rain and melted snow fall in a typical year.
Source: NOAA 1991–2020 climate normals, Wappapello Dam, MO weather station (16 miles away).
1,573 jobs at 196 businesses in Wayne County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
7 doctors and other health care providers list an office in Greenville.
Nearest hospitals
Providers with an office here
| Nurse practitioners and physician assistants | 2 |
|---|---|
| Mental health providers | 2 |
| Physical and occupational therapists | 3 |
| Pharmacies | 1 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (2 nearby)
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Public schools here are run by Greenville R-II. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Greenville Elem.Greenville | Pre-K–6 | 275 | Public | 1.5 mi |
| Greenville Jr.. HighGreenville | 7–8 | 101 | Public | 1.6 mi |
| Greenville HighGreenville | 9–12 | 209 | Public | 1.6 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools. Listed by address; we don’t rate schools.
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Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.