Isola is a town in Humphreys County, Mississippi, home to about 861 people across 0.7 square miles. Its ZIP code is 38754.
Homes sold for a median of $58 per square foot in the three months ending August 2026, a seller’s market.
Each card is that ZIP code’s whole market, including any part outside Isola. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
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| Nearest major airport | Frederick W. Smith International Airport (MEM)129 miles away |
|---|---|
| Closer regional airport | Mid Delta Regional Airport (GLH)27 miles away |
| Nearest city of 250,000+ | Memphis, TN134 miles away |
| Nearest city of 1 million+ | Dallas, TX358 miles away |
Straight-line distances from the center of Isola; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Isola had 638 residents in the 2020 census, down 17% since 2000.
It’s the 212th largest of 420 towns in Mississippi by population.
Humphreys County grew from 19,192 residents in 1920 to 7,785 in 2020.
Humphreys County, 1920–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 91°F in summer, and winter lows average 36°F. About 57.4 inches of rain and melted snow fall in a typical year, with about 0 inches of snow.
Source: NOAA 1991–2020 climate normals, Belzoni, MS weather station (8 miles away).
1,426 jobs at 132 businesses in Humphreys County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
1 doctors and other health care providers list an office in Isola.
Nearest hospitals
Providers with an office here
| Mental health providers | 1 |
|---|
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
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Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.