Middletown is a city in Des Moines County, Iowa, home to about 322 people across 0.6 square miles. Its ZIP code is 52638.
Homes sold for a median of $141 per square foot in the three months ending August 2026, a seller’s market.
Each card is that ZIP code’s whole market, including any part outside Middletown. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up Middletown’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | Des Moines International Airport (DSM)134 miles away |
|---|---|
| Closer regional airport | Southeast Iowa Regional Airport (BRL)8 miles away |
| Nearest city of 250,000+ | St. Louis, MO161 miles away |
| Nearest city of 1 million+ | Chicago, IL198 miles away |
Straight-line distances from the center of Middletown; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
Middletown had 363 residents in the 2020 census, down 32% since 2000.
It’s the 585th largest of 1,019 towns in Iowa by population.
Des Moines County grew from 35,989 residents in 1900 to 38,910 in 2020.
Des Moines County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 85°F in summer, and winter lows average 16°F. About 37.9 inches of rain and melted snow fall in a typical year.
Source: NOAA 1991–2020 climate normals, Burlington Muni Ap, IA weather station (8 miles away).
18,107 jobs at 1,065 businesses in Des Moines County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
Nearest hospitals
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances.
Pharmacies
Libraries
Theaters and performance venues
Counts are within about 1 mile of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
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Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.