South San Francisco is a city in San Mateo County, California, home to about 64,305 people across 9.2 square miles. Its ZIP codes are 94080 and 94128.
Homes sold for a median of $848 per square foot in the three months ending August 2026, a seller’s market.
Mostly South San Francisco
Mostly South San Francisco
Each card is that ZIP code’s whole market, including any part outside South San Francisco. Seller’s market: under 4 months of supply; buyer’s market: over 6. Methodology
We’re writing up South San Francisco’s story and what everyday life there is like, for people thinking about moving in.
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| Nearest major airport | San Francisco International Airport (SFO)4 miles away |
|---|---|
| Nearest city of 250,000+ | Oakland, CA13 miles away |
| Nearest city of 1 million+ | Los Angeles, CA337 miles away |
Straight-line distances from the center of South San Francisco; driving is longer.
Source: Airports from OurAirports (scheduled passenger service); city centers and populations from the U.S. Census Bureau.
Source: Members of Congress from the congress-legislators project; districts from the Census Bureau’s relationship files; governor and mayor from Wikidata.
South San Francisco had 66,105 residents in the 2020 census, up 9% since 2000.
It’s the 143rd largest of 1,563 towns in California by population.
San Mateo County grew from 12,094 residents in 1900 to 764,442 in 2020.
San Mateo County, 1900–2020
Source: U.S. Census Bureau decennial censuses (counties 1900–1990 from the Bureau’s historical county file).
Average highs peak around 75°F in summer, and winter lows average 45°F. About 19.6 inches of rain and melted snow fall in a typical year.
Source: NOAA 1991–2020 climate normals, San Francisco Intl Ap, CA weather station (4 miles away).
477,938 jobs at 21,569 businesses in San Mateo County. The biggest industries by employees:
Source: U.S. Census Bureau County Business Patterns 2023 (private employers; jobs counted where people work).
727 doctors and other health care providers list an office in South San Francisco’s ZIP codes.
Nearest hospitals
Providers with an office here
| Primary care doctors | 87 |
|---|---|
| Specialist doctors | 173 |
| Dentists | 83 |
| Nurse practitioners and physician assistants | 84 |
| Mental health providers | 181 |
| Physical and occupational therapists | 87 |
| Optometrists | 17 |
| Chiropractors | 15 |
| Pharmacies | 15 |
Source: Hospitals from CMS Hospital General Information (ratings are CMS overall star ratings); straight-line distances; providers from the CMS National Plan and Provider Enumeration System (NPPES), by practice address and primary specialty.
Parks (32 nearby)
Grocery stores (10 nearby)
Pharmacies (4 nearby)
Libraries (3 nearby)
Museums
Theaters and performance venues
Counts are within about 2 miles of the center of town.
Source: Map data © OpenStreetMap contributors (openstreetmap.org/copyright), as mapped by volunteers; it can miss places or include closed ones.
Established in 1908.
Source: Wikidata (wikidata.org), the free knowledge base; people are listed by place of birth.
Public schools here are run by South San Francisco Unified. Check each district’s attendance zones for a specific address.
| School | Grades | Students | Type | Distance |
|---|---|---|---|---|
| Buri Buri ElementarySouth San Francisco | K–5 | 584 | Public | 1.3 mi |
| Hillside ElementarySouth San Francisco | K–5 | — | Public | 0.9 mi |
| Los Cerritos ElementarySouth San Francisco | K–5 | 304 | Public | 0.4 mi |
| Martin ElementarySouth San Francisco | K–5 | 370 | Public | 0.8 mi |
| Ponderosa ElementarySouth San Francisco | K–5 | 359 | Public | 0.9 mi |
| Spruce ElementarySouth San Francisco | K–5 | 384 | Public | 0.4 mi |
| Sunshine Gardens ElementarySouth San Francisco | K–5 | 329 | Public | 1.0 mi |
| Alta Loma MiddleSouth San Francisco | 6–8 | 652 | Public | 1.6 mi |
| Community DaySouth San Francisco | 6–12 | — | Alternative Education | 0.4 mi |
| Parkway Heights MiddleSouth San Francisco | 6–8 | 573 | Public | 0.5 mi |
| Westborough MiddleSouth San Francisco | 6–8 | 498 | Public | 2.3 mi |
| Baden High (Continuation)South San Francisco | 9–12 | 130 | Alternative Education | 0.9 mi |
| El Camino HighSouth San Francisco | 9–12 | 1,053 | Public | 1.3 mi |
| South San Francisco HighSouth San Francisco | 9–12 | 1,239 | Public | 0.6 mi |
| School | Grades | Students | Affiliation | Distance |
|---|---|---|---|---|
| All Souls Catholic Elementary SchoolSouth San Francisco | Pre-K–8 | 218 | Roman Catholic | 0.4 mi |
| Hillside Christian AcademySouth San Francisco | Pre-K–7 | 49 | Christian (no specific denomination) | 0.8 mi |
| Mills MontessoriSouth San Francisco | Pre-K–K | 15 | Nonsectarian | 0.9 mi |
| Building Kidz of Ssf IncSouth San Francisco | TK | 6 | Nonsectarian | 0.2 mi |
Source: U.S. Department of Education, NCES: Common Core of Data (2024-2025) for public schools; Private School Universe Survey (2023-2024) for private schools. Listed by address; we don’t rate schools.
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Town boundaries don’t always match ZIP codes: a ZIP code can cross into neighboring towns, and a town can share a ZIP code with its neighbors. Facts describe the town itself; market figures describe whole ZIP codes.